Reduction of Side Affects of Anticancer Drugs
by Active Hexose Correlated Compound (AHCC)
Sun. B., Mukoda, T., Kosuna, K., and Okada, F.
Bio-Chemistry Department. Amino Up Chemical, Co. Ltd, and Cancer
Institute. Hokkaido University School of Medicine, Sapporo, Japan.
Proceedings of the American Association for Cancer Research.
Volume 40 March 1999
Active Hexose Correlated Compound (AHCC), mycelia extracts of
cultured basidiomycetes, was examined in animal models to relieve
side effects, such as anemia, alopecia and liver injury induced
by anticancer drugs. 1. Male ddY mice were treated with fluorouracil
(5-FU, 50 mg/kg) or cyclophosphamide (CY, 100 mg/kg) or both daily
for 14 days by l.p. and AHCC was given in a 5% diet (or the same
period. Treatment with 5-FU or/and CY resulted in body weight
loss, decrease in the numbers of peripheral cells in blood and
polychromatic erythro-cyles in bone marrows and were significantly
restored by coadministration with AHCC. 2. Male and female SD
rats received cytosine arabinoside (Ara-C, Lp., 50 mg/kg. daily)
for 7 days. AHCC was given for the same period by either p.o. (500 mg/kg). Lp. (500 mg/kg) or local swabbing 0% AHCC-solution). The rats treated with Ara-C showed severe alopeda (50-100% hair
toss). However, coadminls-tration of Ara-C with AHCC protected
from alopecia, especially when AHCC was given p.o. in which only
slight alopeda (0-50% hair loss) was observed. 3. Male ddY mice
were treated with mercaptopurine (6-MP, 30 mg/kg) and metholrexate
(MTX. 2.5 mg/kg) by p.o. tor 4 weeks. AHCC was given at a dose
of 1 g/kg simultaneously. Treatment with 6-MP and MTX resulted
in the decreases of body weight gain, serum albumin and triglyceride
levels, liver drug-metabolism enzyme activities and the increases
of liver weights. sGPT and sGOT levels obviously. The liver injury
was significantly improved by the coadministratlon with AHCC. The results show that AHCC relieved the side effects induced by
anticancer drugs in animals.